Publications and Presentations
This page includes scientific papers published as a result of this project, conference presentations about the project and general Information on the project, e.g. project presentation, brochures, posters and relevant papers by partners.
Scientific Papers
- Thomson J.P, Hunter J.M, Lempiainen H, Muller A, Terranova R, Moggs J.G, Meehan R.R. (2013) Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver. Nucleic Acid Research, 1-16 www.oxfordjournals.org
- Wrzodek C, Eichner J, Buchel F, Zell A (2013) InCroMAP: Integrated analysis of cross-platform MicroArray and Pathway data. Bioinformatics, 29 (4): 506-508 www.oxfordjournals.org.
- Lempiainen.H, Couttet.P, Bolognani.F, Muller.A et al. (2013) Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion. Toxicological Sciences 131(2):375-386 www.oxfordjournals.org.
- Wrodek.C, Eichner.J, Zell.A. (2012) Pathway-based visualisation of cross-platform microarray datasets. Bioinformatics. 28(23):3021-6.www.oxfordjournals.org.
- Thomson.J.P, Lempiainen.H, Hackett.J.A, Nestor.C.E, Muller. A, Bolognani.F, Oakley.E.J, Schubeler.D, Terranova.R, Reinhardt.D, Moggs.J.G, Meehan.R.R. (2012) Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome. Genome Biology 13 (10) :R93 www.genomebiology.com
- Schmid A, Schmitz J, Mannheim J.G, Maier F.C, Fuchs K, Wehrl H.F, Pichler B.J (2012) Feasibility of Sequential PET/MRI Using a State of- the-Art Small Animal PET and a 1 T Benchtop MRI. Molecular Imaging and Biology www.springer.com
- Wrzodek C, Buchel F, Hinselmann G, Eichner J, Mittag F, et al. (2012) Linking the Epigenome to the Genome: Correlation of Different Features to DNA Methylation of CpG Islands. PLoS ONE 7(4): e35327. www.plosone.org
- Schmid A, Rignall B, Pichler BJ, Schwarz M (2012) Quantative Analysis of the Growth Kinetics of Chemically-Induced Mouse Liver Tumors by Magnetic Resonance Imaging. Toxicological Sciences. 126 (1): 52-59 www.oxfordjournals.org.
- Lempiainen H, Muller A, Brasa S, Teo S-S, Roloff T-C, et al. (2011) Phenobarbital Mediates an Epigenetic Switch at the Constitutive Androstane Receptor (CAR) Target Gene Cyp2b10 in the Liver of B6C3F1 Mice. PLoS ONE 6(3): e18216. www.plosone.org
Book Chapters
- Lempiainen.H, et al (2012) Epigenomics for Drug Safety Sciences. In Sahu. S.C (Ed), Toxicology and Epigenetics (pp365-386), John Wiley and Sons Ltd.
Conference Presentations
- Jonathan Moggs - Mechanistic insight and biomarker discovery via integrated epigenomic and transcriptomic profiling - ILSI Health and Environmental Sciences Institute, Human Cancer Risk Assessment Workshop, Paris, France, 17th May 2013
- Marzieh Nejabat - Development of Mechnism Based Markers to Predict Non-Genotoxic Hepatocarcinogens in Early Drug Development - Austrian Society of Toxicology Symposium, Vienna, Austria, 21 March 2013
- Teresa Reigler -The Mesenchymal - Parenchymal Interactions are Critical for Tumor Promotion by Phenobarbital - Austrian Society of Toxicology Symposium, Vienna, Austria, 21 March 2013
- Florian Kellner - Adaptive Responses of Preneoplastic Hepatoctyes: Essential for Tumor Promotion by Non-Genotoxic Hepatocarcinogens? - Austrian Society of Toxicology Symposium, Vienna, Austria, 21 March 2013
- Eva Zeller - Long non-coding RNA Gtl2/Meg3 and its role in hepatic cancer - 17th International AEK Cancer Congress, Heidelberg, Germany, 20th March 2013
- Eva Zeller - Long non-coding RNA Gtl2/Meg3 and its role in hepatic cancer - 79th annual meeting of the Association of DGPT, Halle/Saale, Germany, 6th March 2013
- Markus Templin - Protein Microarray Technologies - Analysis of Signaling Networks in Human Tumours - Key note presentation, Advances in Microarray Technology, Barcelona, Spain, 5th March 2013
- Jonathan Moggs - Epigenetic Mechanisms and biomarkers for non-genotoxic carcinogenesis - Swiss Society of Toxicology Meeting, Basel, Switzerland, 22nd November 2012
- John Thomson - The Potential of Chemicals to Cause Epigenetic Alterations - European Environmental Mutagen Society Conference, Warsaw, Poland, 16th September 2012
- Roland Wolf - Application of Transgenic Animal Models to Predict Human Responses to Drugs and Chemical Toxins - Gordon Research Conference, Holderness, New Hampshire, 11th July 2012
- Lynsey Chatham - Induction of oxidative stress by non-genotoxic carcinogens in a haem oxygenase 1 reporter mouse model - 7th International Meeting on Heme Oxygenases and Related Enzymes, Edinburgh, UK, 28th May 2012
- Raphaelle Luisier - Prediction of early regulatory networks underlying liver non-genotoxic carcinogenesis upon xenobiotic exposure - Integrative Network Biology 2012: Network Medicine, Copenhagen, Denmark, 12th May 2012
- Andreas Schmid - Feasibility of sequential PET and 1T bench-top-MRI studies - Nuclear Medicine 2012, Bremen, Germany, 26th April 2012
- Federico Bologani - Comprehensive mapping of transcriptional and epigenetic perturbations in vivo identifies noncoding RNAs as novel biomarkers for liver tumor promotion - SOT 2012, San Francisco, California, 11th March 2012
- Jonathan Moggs - Epigenomics - Impact for Drug Safety Science - SOT 2012, San Francisco, California, 11 March 2012
- Harri Lempiainen - Epigenomics - Impact for Drug Safety Science - IMI SafeSciMet Course 4.5 Mutagenesis/Carcinogenesis, Vienna, Austria 30th November 2011
- Simon Plummer - Integrated miRNA Microarray analysis in the contect of nongenotoxic rodent hepatocarcinogenesis - 47th Congress of the European Society of Toxicology (EUROTOX 2011), Paris, France 30th August 2011
- Jonathan Moggs - Integrating epigenomic and transcriptomic biomarkers in rodent models of non-genotoxic hepatocarcinogenesis - 47th Congress of the European Society of Toxicology (EUROTOX 2011), Paris, France 29th August 2011
- Richard Meehan - The use of a transgenic reporter model to evaluate the potential of chemicals to cause an epigenetic alteration - 47th Congress of the European Society of Toxicology (EUROTOX 2011), Paris, France 29th August 2011
- Harri Lempiainen - Investigating Epigenetic Mechanisms of Drug-Induced Non-Genotoxic Carcinogenesis (NGC) - Epigenomics of Common Diseases conference, Cambridge UK 13th August 2011
- Colin Henderson - Transgenic models in toxicology - Scottish Toxicology Interest Group, Aberdeen, UK 15th June 2011
- Colin Henderson - The application of transgenic models to study mechanisms of drug and chemical toxicity - ADMET 2011, Munich, Germany 28th March 2011
- Jonathan Moggs - Epigenetic mechanisms and biomarkers of non-genotoxic carcinogenesis - British Toxicology Society & The Dutch Society of Toxicology - Joint Congress, Durham, UK 27th March 2011
- Jonathan Moggs - One way the liver changes itself - demethylation epigenetics - FDA/CDER Drug Induced Liver Injury Workshop, Washington D.C. 24th March 2011
- Jonathan Moggs - Epigenomics - Impact for Translational Sciences - 6th Annual Biomarkers Congress & 1st Oncology Biomarkers Congress, Manchester, UK 21st February 2011
- Remi Terranova - Investigating Epigenetic Mechanisms of Drug-Induced Non-Genotoxic Carcinogenesis - Gordon Conference: Genetics and Epigenetics of Cancer, Ventura, CA 17th January 2011
- Stephane Dhalluin - MARCAR, A new innovative medicines initiative project focusing on non-genotoxic carcinogenesis Insights into the Innovative Medicines Initiative MARCAR project (2010-2014) BioMARkers& molecular tumorclassification for non-genotoxicCARcinogenesis - Preclinical Safety and Efficacy testing of biological products, Berlin, Germany 1-2 December 2010
- Harri Leimpanien - Epigenomics, Impact for Drug Safety Sciences - UK Advanced Toxicology Course on Epigenetics, Harrogate, UK 16th & 17th November 2010
- Stephane Dhalluin - Insights into the Innovative Medicines Initiative MARCAR project (2010-2014) BioMARkers& molecular tumorclassification for non-genotoxicCARcinogenesis - Carcinogenicity and genotoxicity conference, London, UK 19-20 October 2010
- Jonathan Moggs - Epigenomics, Impact for Drug Safety Sciences -Hamner Institutes (US Centre for Drug Safety Sciences) NC, USA, 11th October 2010
- Jonathan Moggs - Epigenomics, Impact for Drug Safety Sciences - Toxicogenomics & Xenobiotic/Drug Safety at ISSX 9th International Meeting, Istanbul, Turkey, 4th - 8th September 2010
- Tom Shepherd - Liver mRNA & miRNA Profilling of Phenobarbital Treated PXR/CAR Double Knock-out & Humanised Mice Provides Insights into Mechanism(s) of PB-Mediated Mouse Hepatocarciongenesis - Society of Toxicology, 49th Annual Meeting and ToxExpo, Salt Lake City, Utah, USA 8-11 March 2010
- Jonathan Moggs - Epigenomics, Impact for Drug Safety Sciences - 5th Annual International Conference on Predictive Human Toxicity and ADME/Tox Studies. Brussels, Belgium, 28th - 29th January 2010
General Information
- 14th June 2010 - MARCAR Coordinator Dr Jonathan Moggs gave a presentation on the MARCAR project to the IMI JU Stakeholder Meeting - view presentation
- 5th October 2011 - MARCAR Coodinator Dr Jonathan Moggs gave a presentation at the EFPIA Meeting with EMA and FDA titled "MARCAR consortium focus on novel mechanisms& biomarkers for non-genotoxic carcinogenesis"
- 9th October 2012 - MARCAR Coordinator Dr Jonathan Moggs gave a presentation on New developments and opportunities for enhancing preclinical carcinogenicity testing strategies at the BioSafe Annual Leadership Meeting.